Drug Standards
Medchemexpress LLC Gemcitabine hydrochloride (Standard) | 122111-03-9 | 99.94% | 299.66 | 25 MG
Gemcitabine hydrochloride (Standard) serves as the analytical standard for Gemcitabine (hydrochloride), primarily for research and analytical applications. This product, also known as LY 188011 Hydrochloride, is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent that functions by inhibiting DNA synthesis and repair, ultimately inducing autophagy and apoptosis.
- Analytical standard for research and analytical applications.
- Functions as a pyrimidine nucleoside analog antimetabolite.
- Acts as an antineoplastic agent.
- Inhibits DNA synthesis and repair.
- Induces autophagy and apoptosis.
- Utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
Sigma Aldrich Fine Chemicals Biosciences Ethyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | 120-47-8 | MFCD00002353 |
Ethyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 166.17 | 120-47-8 | MFCD00002353 |
Sigma Aldrich Fine Chemicals Biosciences Methyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | 99-76-3 | MFCD00002352 |
Methyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 152.15 | 99-76-3 | MFCD00002352 |
Medchemexpress LLC N-acetyl mesalazine | 51-59-2 | 99.9% | C9H9NO4 | 5 MG
N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid and serves as a biomarker for evaluating its efficacy. It can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. This compound can be used in the study of diseases such as colitis and colon cancer.
- Primary intestinal metabolite of 5-aminosalicylic acid
- Serves as a biomarker for evaluating efficacy of 5-aminosalicylic acid
- Scavenges free radicals
- Reduces DNA base hydroxylation
- Ameliorates mucosal inflammation
- Can be used in the study of diseases such as colitis and colon cancer
- Inhibits OH radical-stimulated DNA base hydroxylation in calf thymus DNA
Medchemexpress LLC 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole | 1231930-33-8 | MFCD16660227 | C11H12BrFN2 | 500 G
Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) is a drug intermediate used for the synthesis of various active compounds. It is intended for use as a laboratory chemical and in the manufacture of substances. This product is for research use only and has not been fully validated for medical applications.
- Functions as a drug intermediate
- Appears as a solid
- Molecular weight of 271.13
- Stable under recommended storage conditions
- Store powder at -20°C for up to 3 years or 4°C for up to 2 years
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month
Medchemexpress LLC Naproxen (Standard) | 22204-53-1 | C14H14O3 | 250 MG
Naproxen (Standard) is the analytical standard of Naproxen, intended for research and analytical applications. It acts as a COX-1 and COX-2 inhibitor and is commonly used in qualitative, quantitative, and methodological research experiments. This product is for research use only.
- Analytical standard
- Intended for research and analytical applications
- Functions as a COX-1 and COX-2 inhibitor
- Used in HPLC, GC, and MS research experiments
- IC50: 8.72 μM (COX-1)
- IC50: 5.15 μM (COX-2)
Selleck Chemical LLC Methotrexate S1210-500mg
Methotrexate analog of folic acid is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells It forms an inactive ternary complex with DHFR and NADPH Methotrexate (MTX) induces apoptosis
Selleck Chemical LLC Cabazitaxel S3022-10mM/1mL
Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly processes that are essential for cells to divide Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway
Apexbio Technology LLC Ethacrynic Acid 58-54-8 200mg
Ethacrynic acid (CAS 58-54-8) is a small molecule loop diuretic that exerts its effects by inhibiting the Na sup /sup -K sup /sup -2Cl sup /sup cotransporter (NKCC2) localized in the thick ascending limb of the loop of Henle This inhibition interrupts reabsorption of sodium potassium and chloride ions leading to increased concentrations of these electrolytes in the renal tubular fluid and decreased medullary osmolarity As a result water reabsorption is reduced promoting diuresis and subsequent urinary excretion Ethacrynic acid is frequently utilized in research investigating renal function electrolyte transport mechanisms and pathophysiology of edematous states including heart failure nephrotic syndrome and hepatic conditions
Medchemexpress LLC Voriconazole | 137234-62-9 | 99.89% | C16H14F3N5O | 1 ML
Voriconazole is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis by inhibiting 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes. It can penetrate the blood-brain barrier (BBB).
- Inhibits fungal ergosterol biosynthesis
- Penetrates the blood-brain barrier
- Potent activity against S. apiospermum and C. neoformans
- Inhibits cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase
Apexbio Technology LLC Manidipine 2HCl 89226-75-5 200mg
Manidipine 2HCl (CAS 89226-75-5) is a dihydropyridine-derived small molecule that functions as a calcium channel blocker It selectively inhibits L-type voltage-gated Ca2 channels impeding calcium influx across cell membranes Manidipine 2HCl demonstrates potent inhibitory activity with an IC50 value of 2 6 nM for Ca2 current reduction This compound is utilized in biomedical research to investigate the physiological and pharmacological roles of calcium signaling particularly in cardiovascular and smooth muscle cell function and to explore mechanisms related to calcium-dependent processes
Apexbio Technology LLC Naphazoline HCl 550-99-2 10g
Naphazoline HCl (CAS 550-99-2) is a synthetic imidazoline derivative that acts as a sympathomimetic amine It primarily targets -adrenergic receptors on vascular smooth muscle inducing vasoconstriction through the activation of these receptors This property leads to reduced blood flow and decreased vascular congestion particularly in ocular tissues Naphazoline HCl is frequently employed in research to investigate adrenergic signaling pathways and to model vasoconstrictive mechanisms in vitro and in vivo Its pharmacological profile makes it a valuable tool for studies involving vascular responses and ocular pharmacodynamics
Medchemexpress LLC Esazomide impurity 11 | 69125-10-6 | C3H2ClN3O2 | 100 MG
Esazomide impurity 11 is a chemical compound for laboratory research and the manufacture of substances. It serves as an impurity of Esazomide and is also used as a reference standard.
- A chemical compound for laboratory use
- Identified as an impurity of Esazomide
- Molecular formula: C3H2ClN3O2
- Molecular weight: 147.52
- Appearance: Solid
- Store container tightly sealed in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
- Recommended storage at 4°C under nitrogen
- In solvent, store at -80°C for 6 months or -20°C for 1 month under nitrogen
Sigma Aldrich Fine Chemicals Biosciences Colchicine 95 HPLC powder1G
Colchicine is a secondary metabolite which has anti-inflammatory properties. It is used to treat gout crystal-induced joint inflammation familial Mediterranean fever BehA§et disease vasculitides andnbsppericarditis. Colchicine inhibits cell division intracellular vesicle motility secretion of cytokines andnbspchemokines. It is implicated innbspleukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.
Sigma Aldrich Fine Chemicals Biosciences Primidone | 125-33-7 | MFCD00038662 | 150mg
Primidone | Mol Wt: 218.25 | 125-33-7 | MFCD00038662 | 150mg